It’s a well-known radiology dilemma: Dense breast tissue makes it difficult to detect tumors in X-rays of the female breast. Yet, the risk of carcinoma also rises with breast density. The challenge here is that mammograms become less accurate for women who are more likely to develop breast cancer. So, what are the options for women with dense breast tissue, when it comes to offering them tailored early breast cancer detection? And can these strategies also be implemented for routine screenings?